I am investigating cancer biology with the tools of
bioinformatics and statistics at IRIBHM, a
laboratory of the Free
University of Brussels.
I formerly held research positions at the Santa Fe Institute, at the
Theoretical Biology and
Biophysics Group which is part of the Los Alamos National
Laboratory (USA), and at IRIDIA, also a laboratory
of the Free University of Brussels.
Peer reviewed articles (download related data sets here)
Venet D., Dumont
J.E. & Detours V. (2011), Most Random Gene Expression
Signatures are Significantly Associated with Breast Cancer
Outcome, PLoS Computational
Biology 7(10), e1002240, (full text).
Lambert N., Lambot
M.A., Bilheu A., Albert V., Englert Y., Libert F., Noel J.C.,
Sotiriou C., Holloway A.K., Pollard K.S., Detours V. &
Vanderhaeghen P. (2011) Genes Expressed in Specific Areas of the
Human Fetal Cerebral Cortex Display Distinct Patterns of
evolution, PLoS One
6(3), e17753 (abstract,
full
text).
Maenhaut C., Detours V., Dom G., Handkiewicz-Junak D., Oczko-Wojciechowska M. & Jarzab B. (2011), Gene Expression Profiles of Radiation-induced Thyroid Cancers, Clin. Oncol. 23(4), p282-8 (abstract).
van Staveren W.C.,
Solis D.Y., Hebrant A., Detours V., Dumont J.E. & Maenhaut C.
(2009), Human Cancer Cell Lines: Experimental Models for Cancer
Cells In Situ? Cancer Stem Cells? BBA Reviews 1795(2) p92-103 (abstract).
Detours, V., Versteyhe, S., Dumont J.
E. & Maenhaut C., (2008), Gene Expression Profiles of
Post-Chernobyl Thyroid Cancers, Curr. Op. in Endocrinol.,
Metabolism and Diabetes 15, p440-5 (abstract,
full
text).
Burniat, A., Jin, L., Detours, V., Driessens, N.,
Goffard, J.C., Santoro, M., Rothstein, J., Dumont, J.E., Miot,
F. & Corvilain B., (2008), Gene
Expression in RET/PTC3 and E7 Transgenic Mouse Thyroids:
RET/PTC3 but not E7 Tumors are Partial and Transient Models of
Human Papillary Thyroid Cancers. Endocrinology 149, p5107-17 (abstract,
full
text).
Detours,
V., Delys, L., Libert, F., Weiss Solís, D., Bogdanova,
T., Dumont, J. E., Franc, B., Thomas, G. & Maenhaut, C.,
(2007), Genome-wide Gene Expression Profiling Suggests Distinct
Radiation Susceptibilities in Sporadic and Post-Chernobyl
Papillary Thyroid Cancers, British J. Cancer 97, 818-25 (abstract,
full
text).
van Staveren WC, Solís DW, Delys L, Duprez L,
Andry G, Franc B, Thomas G, Libert F, Dumont JE, Detours V,
Maenhaut C., (2007), Human thyroid tumor
cell lines derived from different tumor types present a common
dedifferentiated phenotype, Cancer Res. 67(17):8113-20 (abstract,
full
text).
Delys, L.,
Detours, V., Franc, B., Thomas, G., Bogdanova, Tronko, M., T.,
Libert, F., Dumont, J. E. &
Maenhaut, C., (2007), Gene expression and the biological phenotype of
papillary thyroid carcinomas, Oncogene 26(57),
7894-903 (abstract,
full
text).
Song Y, Driessens N, Costa M, De Deken X, Detours V,
Corvilain B, Maenhaut C, Miot F, Van Sande J, Many MC, Dumont
JE, (2007), Roles of hydrogen peroxide in thyroid physiology and
disease, J Clin Endocrinol Metab. 92(10), 3764-73 (abstract,
full
text).
van
Staveren, C. G., Detours, V., Dumont, J. E., & Maenhaut, C.,
(2006), Negative
feedbacks in normal cell growth and their suppression in
tumorigenesis. Cell Cycle 5, 571-572 (full
text).
van
Staveren, C. G., Weiss, D., Delys, L., Venet, D., Cappello, M.,
Andry, G., Dumont, J. E., Libert, F., Detours, V., &
Maenhaut, C., (2006), Gene Expression in TSH-treated Human Thyrocytes and
Autonomous Adenomas: Suppression of Negative Feedbacks in
Tumorigenesis, Proc.
Nat. Acad. Sci. USA 103, 413–418 (abstract,
full
text).
Detours,
V., Dumont, J. E., & Maenhaut, C., (2006), Systems Biology,
Cell Specificity and Physiology, in Theories in
Medicine, Paton R. & McNamara L. Eds. Elsevier (full
text).
Wattel,
S., Mircescu, H., Venet, D., Burniat, A., Franc, B., Frank, S.,
Andry, G., Van Sande, J., Rocmans, P., Dumont, J. E., Detours,
V. & Maenhaut, C., (2005), Gene Expression in Thyroid
Autonomous Adenomas Provides Insight on their
Physiopathology, Oncogene 24,
6902-16 (abstract,
full
text).
Detours,
V., Wattel, S., Venet, D., Hutsebaut, N., Bogdanova, T., Tronko,
M. D., Dumont, J. E., Franc, B., Thomas, G. & Maenhaut, C.,
(2005), Absence of a Specific Radiation Signature in
Post-Chernobyl Thyroid Cancers, British J. Cancer 92,
1545-1552 (abstract,
full
text).
Detours, V., Dumont, J. E., Bersini,
H., & Maenhaut, C., (2003). Integration and Cross-Validation
of High-Throughput Gene Expression Data: Comparing Heterogenous
Data Sets, FEBS Lett. 546, 98-102 (abstract,
full
text).
Yusim, K., Kesmir, C., Addo, M. M.,
Altfeld, M., Gaschen, B., Chigaev, A., Detours, V. & Korber,
B. T., (2002), Clustering Patterns of CTL Epitopes in HIV-1
Proteins Reveal Imprints of Immune Evasion on HIV-1 Global
Variation, J. Virology, 76(17), 8757-8768 (abstract,
full
text).
Kesmir, C. Nussbaum, N. K., Shild, H.,
Detours, V., Brunak, S., (2002), Prediction of Proteasome
Clivage Motifs by Neural Networks, Protein Engeneering,
15(4), 287-296 (abstract,
full
text).
Korber, B. T., Gaschen, B., Yusim, K.,
Thakallapally, R., Kesmir, C. & Detours, V., (2001),
Evolutionary and Immunological Implications of Contemporary
HIV-1 Variation, Brit. Med. Bull., 58, 19-42 (abstract,
full
text).
Detours, V. & Perelson, A. S.,
(2000), The Paradox of Alloreactivity and Self MHC Restriction:
Quantitative Analysis and Statistics, Proc. Nat. Acad. Sci.
USA, 97, 8479-8483 (abstract,
full
text).
Detours, V., Mehr, R., & Perelson,
A. S., (2000), Deriving Quantitative Constraints Under Which
T Cell Selection Operates from Data on the Mature
T Cell Repertoire, J. Immunol. 164, 121-128 (abstract,
full
text).
Detours, V., Mehr, R., & Perelson,
A. S., (1999) A Quantitative Theory of Affinity-Driven T Cell
Repertoire Selection, J. theor. Biol. 200, 389-403 (abstract,
full
text).
Detours, V., & Perelson, A. S.,
(1999), Explaining High Alloreactivity as a Quantitative
Consequence of Affinity-Driven T Cell Selection, Proc. Nat.
Acad. Sci. USA 96, 5153-5158 (abstract,
full
text).
Detours, V., Sulzer, B., & Perelson
A. S., (1996), Size and Connectivity of the Idiotypic Network
are Independent of the Discreteness of the Affinity
Distribution, J. theor. Biol. 183, 408-416 (abstract,
full
text).
Bersini, H., & Detours, V., (1994),
Asynchrony Induces Stability in Cellular Automata Based Models,
in Proceedings of the Fourth Conference on Artificial Life,
Brooks, R. A., Maes, P., Eds. MIT Press (full
text).
Detours,V.,
Bersini, H., Stewart, J., Varela, F. J., (1994), Development of
Idiotypic Network in Shape Space, J. theor. Biol. 170,
401-414 (abstract,
full
text).
Thesis
1.
Detours,
V.,
(1996), Modèles Formels de la Sélection des
Cellules B et T, Ph. D dissertation,
Université Paris 6.
2. Detours, V., (1992), Simulations
du Réseau Idiotypique, Master thesis, École
des Hautes Études en Sciences Sociales, École
Polytechnique, Université Paris 6.